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KMID : 0615720160330030145
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Jouranl of Korean Acupuncture and Moxibustion society
2016 Volume.33 No. 3 p.145 ~ p.152
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Factors associated with willingness to participate in clinical trials for cancer patients: an exploratory narrative review
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Kim Kun-Hyung
Hwang Bo-Yown
Son Gyung-Mo
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Abstract
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Objectives: This study aimed to investigate both cancer patients’ willingness to participate (WTP) in clinical trials and its associated factors.
Methods: We searched MEDLINE (PubMed) for studies that had investigated cancer patients’ WTP in clinical trials. Search terms included ‘willingness to participate’, ‘cancer’ and ‘trial’. Studies published within the last five years up to July 26, 2016 were potentially eligible.
Results: Of 44 initial hits, 14 studies (12 quantitative and 2 qualitative) were included. Two out of the 14 studies investigated WTP in an acupuncture trial. Study designs, such as WTP measurement methods, investigation settings, and type of cancer, varied. The proportion of participants with a WTP was widely distributed between the studies (median 48.6 %, range 11.1 % to 88.3 %). Factors associated with WTP included various socio-demographic factors, clinical factors, participants’ knowledge/attitudes toward clinical trials, travel distance, information from physicians, and trust toward physicians.
Conclusions: WTP and its associated factors were variable across the reviewed studies, which might be due to different research methods and contexts. Whether or not common factors associated with cancer patients’ WTP in clinical trials exist remains unclear and thus warrants further research.
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KEYWORD
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Willingness to participate, Cancer, Clinical trial, Literature review
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